• Jong Eun Park, You Hwan Jo, Sung Yeon Hwang, Won Young Kim, Seung Mok Ryoo, Dong-Hyun Jang, Taegyun Kim, Youn-Jung Kim, Seonwoo Kim, Hyun Cho, Gun Tak Lee, Sung Phil Chung, Sung-Hyuk Choi, Tae Gun Shin, Gil Joon Suh, and Korean Shock Society (KoSS) Investigators.
• Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
• Shock. 2022 Jan 1; 57 (1): 818781-87.

IntroductionWe evaluated the effects of vitamin C and thiamine administration on biomarkers in patients with septic shock.MethodsThis was a post-hoc analysis of the Ascorbic Acid and Thiamine Effect in Septic Shock (ATESS) trial, a multicenter, double-blind, randomized controlled trial. Patients were randomized to either a treatment group (intravenous vitamin C and thiamine for 48 h) or a control group. Interleukin (IL)-6, IL-10, angiopoietin-II (AP2), and S100β were assessed at baseline and at 72 h. The primary outcomes were the biomarker levels at 72 h, and the secondary outcome was reduction rate.ResultsForty-five patients were assigned to the treatment group and 52 were assigned to the control group. Baseline biomarker levels and at 72 h were not significantly different between the treatment and the placebo groups. The reduction rates were not significantly different between the two groups. These outcome variables showed fair diagnostic accuracy for predicting 28-day mortality according to the area under the receiver operating characteristic curve.ConclusionVitamin C and thiamine administration during the early phase of septic shock did not significantly change prognostic biomarker levels of IL-6, IL-10, AP2, and S100β.Trial RegistrationNCT, ClinicalTrials.gov NCT03756220, ATESS. Registered 28 November 2018, https://clinicaltrials.gov/ct2/show/NCT03756220.Copyright © 2021 by the Shock Society.

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