• Borja Quiroga, Isabel Galán, García de VinuesaSoledadSNephrology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain., Marian Goicoechea, Úrsula Verdalles, and José Luño.
• Nephrology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
• Nephrol. Dial. Transplant. 2015 May 1; 30 (5): 801-6.

BackgroundIncreased interarm systolic blood pressure difference (IASBPD) is associated with mortality and cardiovascular (CV) events both in the general population and in patients at high CV risk. The aim of the present study was to assess the value of IASBPD ≥ 10 mmHg for predicting CV events in patients with chronic kidney disease (CKD).MethodsThe study sample comprised 652 patients with CKD (age 67 ± 15 years, 58.1% men). Follow-up was 19 ± 5 months. We recorded increased IASBPD and related factors and assessed the predictive value of this variable for CV events.ResultsWe recorded diabetes mellitus in 136 patients (20.8%), history of CV disease in 213 (32.6%) and dyslipidaemia in 327 (50.1%). The mean glomerular filtration rate was 45.9 ± 18.9 mL/min/1.73 m(2), and the median albumin/creatinine ratio was 26(0-151) mg/g. IASBPD was ≥10 mmHg in 184 patients (28.1%). The factors associated with IASBPD ≥10 mmHg were age, systolic blood pressure levels, history of congestive heart failure, lower levels of high-density lipid cholesterol and higher use of hypertensive drugs. Fifty-eight patients (8.5%) developed a CV event during the follow-up. IASBPD ≥10 mmHg [HR, 1.802, 95%CI (1.054-3.079); P = 0.031] was an independent predictor of CV events.ConclusionsIncreased IASBPD is an independent predictor of CV events in CKD patients.© The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.

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