• M Bennett and R Heard.
• Diving and Hyperbaric Medicine, Prince of Wales Hospital, Barker St, Randwick, NSW, Australia.
• Cochrane Db Syst Rev. 2004 Jan 1; 2004 (1): CD003057CD003057.

BackgroundMultiple Sclerosis (MS) is a chronic, recurrent and progressive illness with no cure. On the basis of speculative pathophysiology, it has been suggested that Hyperbaric Oxygen Therapy (HBOT) may slow or reverse the progress of the disease.ObjectivesThe object of this review was to evaluate the efficacy and safety of HBOT in the treatment of MS.Search StrategyWe searched the Cochrane MS Group trials register (July 2002), the Cochrane Central Register of Controlled Trials (The Cochrane Library, Issue 2, 2002), MEDLINE (January 1966 to October 2002) and the National Library of Medicine (NLM) database (July 2002), along with specialised hyperbaric resources and handsearching of relevant journals and proceedings.Selection CriteriaAll randomised, controlled trials involving a comparison between HBOT and a sham therapy in MS were evaluated.Data Collection And AnalysisTwo reviewers independently appraised all comparative trials identified, extracted data and scored them for methodological quality.Main ResultsWe identified ten reports of nine trials that satisfied selection criteria (504 participants in total). Two trials produced generally positive results, while the remaining seven reported generally no evidence of a treatment effect. None of our three a priori subgroup analyses placed these two trials in the same group and were therefore unable to account for this difference. Three analyses (of 21) did indicate some benefit. For example, the mean Expanded Disability Status Scale (EDSS) at 12 months was improved in the HBOT group (group mean reduction in EDSS compared to sham -0.85 of a point, 95% confidence interval -1.28 to -0.42, P = 0.0001). Only the two generally positive trials reported on this outcome at this time (16% of the total participants in this review).Reviewer's ConclusionsWe found no consistent evidence to confirm a beneficial effect of hyperbaric oxygen therapy for the treatment of multiple sclerosis and do not believe routine use is justified. The small number of analyses suggestive of benefit are isolated, difficult to ascribe with biological plausibility and would need to be confirmed in future well-designed trials. Such trials are not, in our view, justified by this review.

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