• Mohammad Reza Mohammadi, Seyed Kaveh Hojjat, Seyed Ali Mostafavi, Ali Khaleghi, Zahra Hooshyari, Nastaran Ahmadi, Faezeh Kaviyani, and Mina Norozi Khalili.
• Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
• Arch Iran Med. 2021 Jun 1; 24 (6): 478-486.

BackgroundThis study investigated how the parents' personality disorders may be related to substance use disorder in children and adolescents.MethodsThe study was a cross-sectional study in which 28,540 children and adolescents (aged 6 to 18 years) and their parents participated between 2015 and 2016. The diagnosis of substance use was made using the Kiddie Schedule for Affective Disorders and Schizophrenia--Present and Lifetime Version (K-SADS-PL) interview and the personality disorders were assessed using Millon Clinical Multiaxial Inventory - Third Edition (MCMI-III). The parents were also surveyed for their personality assessed with MCMI.ResultsThe results showed that the paranoid personality disorder in father (odds ratio [OR] = 8.34, 95% CI, P = 0.042) and borderline personality disorder in mother (OR = 4.6, 95% CI, P = 0.049) increase the chance of substance use in children.ConclusionThe findings suggest that in designing preventive programs for substance use, the personality characteristics of the parents need to be taken into account.© 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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