• Dagmar Beier, Henriette E Callesen, Louise N Carlsen, Kirsten Birkefoss, Hanna Tómasdóttir, Hanne Wűrtzen, Henrik W Christensen, Lotte S Krøll, Mette Jensen, Christel V Høst, and Jakob M Hansen.
• Department of Neurology, Odense University Hospital and Southern University of Denmark, Odense, Denmark.
• Cephalalgia. 2021 Aug 18: 3331024211034489.

BackgroundMany people suffering from migraine combine pharmacological and non-pharmacological treatments. The purpose of this systematic review is to provide an updated guideline for some widely used non-pharmacological treatment options for migraine.MethodsWe conducted a systematic literature review of randomized studies of adults with migraine treated with manual joint mobilisation techniques, supervised physical activity, psychological treatment, acupuncture and patient education. The main outcomes measured were days with headache and quality of life. Recommendations were formulated based on the Grade of Recommendation, Assessment, Development and Evaluation (GRADE) approach including patient preferences based on expert opinion and questionnaire data.ResultsThe overall level of certainty of the evidence was low to very low. Manual therapy techniques and psychological treatment did not change the studied outcomes. Supervised physical activity might have a positive impact on quality of life, acupuncture on headache frequency, intensity, quality of life and the use of attack-medicine. Patient education might improve self-rated health and quality of life and increase the number of well-informed patients.ConclusionBased on observed effects, the lack of serious adverse events, and patients' preferences, we make weak recommendations for considering the investigated interventions as a supplement to standard treatment.Protocol registration: Prospero CRD42020220132.

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