• Immunol Allergy Clin North Am · Feb 2016

    Review

    Allergy Work-Up Including Component-Resolved Diagnosis: How to Make Allergen-Specific Immunotherapy More Specific.

    • Jörg Kleine-Tebbe, Paolo M Matricardi, and Robert G Hamilton.
    • Allergy & Asthma Center Westend, Outpatient Clinic Hanf, Ackermann & Kleine-Tebbe, Spandauer Damm 130, Haus 9, Berlin D-14050, Germany. Electronic address: kleine-tebbe@allergie-experten.de.
    • Immunol Allergy Clin North Am. 2016 Feb 1; 36 (1): 191-203.

    AbstractSymptoms are recorded by obtaining a clinical history. Allergen sensitization is demonstrated by skin prick test or allergen-specific IgE serology. IgE sensitizations to allergen sources can be identified knowing the relationship between major aeroallergens and homologous allergen families. Some develop allergic sensitization to pan-allergens. Allergen extracts do not allow definitive separation of the sources. IgE antibody analysis of the major allergenic molecules facilitates differentiation of sensitizing allergen sources. IgE sensitizations to inhalant allergens are only relevant in the case of corresponding symptoms. In questionable cases, conjunctival or nasal provocation tests help induce confirmatory symptoms and identify relevant allergens for immunotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

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