• JNMA J Nepal Med Assoc · Feb 2021

    Case Reports

    Herlyn Werner Wunderlich Syndrome Presenting with Ischemic Stroke due to Suspected Paroxysmal Nocturnal Hemoglobinuria: A Case Report.

    • Ayushma Acharya, Prajwala Yogi, Pramod Singh, and Tulsi Ram Bhattarai.
    • Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
    • JNMA J Nepal Med Assoc. 2021 Feb 28; 59 (234): 192-196.

    AbstractParoxysmal nocturnal hemoglobinuria can rarely present as cerebral ischemia and stroke due to arterial thrombosis. However, it should be considered in a young patient with bone marrow failure features, systemic thromboses, and hemolysis. The variants of paroxysmal nocturnal hemoglobinuria pose a diagnostic challenge and hence are important to recognize. We report a case of a 28-years-old female with Herlyn Werner Wunderlich Syndrome who presented with an ischemic cerebrovascular accident, pancytopenia, hemoglobinuria, and widespread abdominal thromboses suggestive of paroxysmal nocturnal hemoglobinuria. The patient was managed symptomatically and referred to a hematologist.

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