• Annals of neurology · Apr 2007

    Clinical Trial

    Hemispherectomy for intractable epilepsy in adults: the first reported series.

    • Shearwood McClelland and Robert E Maxwell.
    • Department of Neurosurgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA. mccl0285@umn.edu
    • Ann. Neurol. 2007 Apr 1;61(4):372-6.

    AbstractHemispherectomy for intractable unihemispheric epilepsy (IUE) has long been established in pediatric patients. This study reports the first series examining hemispherectomy exclusively in adult patients (>18 years old). Nine adults with IUE underwent hemispherectomy at the University of Minnesota. All patients had unilateral hemiplegia and visual field loss. Seven patients (77.8%) were Engel class I/II at last follow-up. Five (83.3%) of the six patients with >30 years of follow-up were seizure free. No surgery-related mortality, hydrocephalus, or superficial cerebral hemosiderosis occurred. Hemispherectomy is an effective procedure in appropriately selected adult patients, resulting in excellent long-term seizure control and no mortality.

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