• Mathieu Jozwiak, Xavier Monnet, and Jean-Louis Teboul.
• Medical Intensive Care Unit, Bicêtre Hospital, Le Kremlin Bicêtre, France;; Inserm UMR S_999, Paris-South University, Le Kremlin Bicêtre, France.
• Ann Transl Med. 2016 Sep 1; 4 (17): 332.

AbstractSepsis bundles represent key elements of care regarding the diagnosis and treatment of patients with septic shock and allow ones to convert complex guidelines into meaningful changes in behavior. Sepsis bundles endorsed the early goal-directed therapy (EGDT) and their implementation resulted in an improved outcome of septic shock patients. They induced more consistent and timely application of evidence-based care and reduced practice variability. These benefits mainly depend on the compliance with sepsis bundles, highlighting the importance of dedicated performance improvement initiatives, such as multifaceted educational programs. Nevertheless, the interest of early goal directed therapy in septic shock patients compared to usual care has recently been questioned, leading to an update of sepsis bundles in 2015. These new sepsis bundles may also exhibit, as the previous bundles, some limits and pitfalls and the effects of their implementation still needs to be evaluated.

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