• J. Pediatr. Surg. · Oct 2017

    Effect of vitamin C on tissue damage and oxidative stress following tunica vaginalis flap coverage after testicular torsion.

    • Maryam Moghimian, Malihe Soltani, Hossein Abtahi, and Majid Shokoohi.
    • Department of Basic Sciences, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Islamic Republic of Iran.
    • J. Pediatr. Surg. 2017 Oct 1; 52 (10): 1651-1655.

    Aim Of The StudyThe aim was to investigate the protective effect of vitamin C on tissue damage and oxidative stress following tunica albuginea incision with tunica vaginalis flap coverage for testicular torsion.Materials And MethodsAdult male Wistar rats were randomly divided into two experimental groups. The first group experienced 5h of testicular torsion followed by treatment with vitamin C alone, with tunica vaginalis flap coverage alone, and with both vitamin C and tunica vaginalis flap coverage along with a control group subjected to a sham procedure. The second group experienced 9h of testicular torsion followed by the same treatment options as described for the 5h group. The oxidative stress and testosterone levels were measured 24h posttreatment. The Johnsen score, diameter of the seminiferous tubules, and thickness of the seminiferous tubule epithelium were recorded 30days following the treatment.ResultsThe Johnsen score, diameter of the seminiferous tubules, and thickness of the seminiferous tubule epithelium significantly increased in the 5h testicular torsion group receiving treatment with vitamin C and tunica vaginalis flap coverage compared with the group receiving tunica vaginalis flap alone. The level of testosterone decreased significantly in all groups except for the 5h testicular torsion group receiving treatment with vitamin C and tunica vaginalis flap coverage. The MDA level also decreased in the group receiving treatment with vitamin C and tunica vaginalis flap coverage compared with the group receiving tunica vaginalis flap coverage alone.ConclusionsThe results showed that the histological parameters and testosterone levels improved with the administration of vitamin C before tunica vaginalis flap coverage in the group experiencing 5h of torsion. This may be a result of the antioxidant effect of vitamin C. No advantage was observed for the 9h group, possibly because the dosage of vitamin C was inadequate.Copyright © 2017 Elsevier Inc. All rights reserved.

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