• Leyla Kazancioglu, Sule Batcik, Medeni Arpa, Basar Erdivanli, Ozergin CoskunZerrinZhttps://orcid.org/0000-0003-3423-6938Department of Otorhinolaryngology, Recep Tayyip Erdogan University, Rize, Turkey., Ozlem Celebi Erdivanli, Ilkay Bahceci, Hizir Kazdal, Ozcan Erel, and Salim Neselioglu.
• Department of Anesthesiology and Reanimation, Recep Tayyip Erdogan University, Rize, Turkey.
• Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14838.

ObjectiveWe aimed to investigate the effects of hypotensive anaesthesia on oxidative stress with serum thiol/disulphide balance in patients undergoing elective septoplasty procedures under general anaesthesia.MethodsSeventy-two patients between the ages of 18-60, with a physical condition I -II, according to the American Society of Anesthesiologists, were included in this prospective observational study. Septoplasty was chosen for standard surgical stress. According to the maintenance of anaesthesia, patients were divided into the groups as Hypotensive Anaesthesia (n = 40) and Normotensive Anaesthesia (n = 32). Serum thiol/disulphide levels were measured by the method developed by Erel & Neşelioğlu.ResultsThe native thiol and total thiol values of both groups measured at the 60th min intraoperatively were significantly lower than the preoperative values (both P < .01). Intraoperatively, at the 60th min, there was no significant difference in terms of post-native thiol and post-total thiol levels between hypotensive and normotensive anaesthesia groups (P = .68 and .81, respectively). Age >40 years and female gender were found to have a significant effect on dynamic oxidative stress (P = .002 and .001, respectively).ConclusionThis pilot study has found that hypotensive anaesthesia had no adverse effect on dynamic thiol/disulphide balance in elective surgeries.© 2021 John Wiley & Sons Ltd.

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