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Emerg. Med. Clin. North Am. · May 2007
ReviewManagement of beta-adrenergic blocker and calcium channel antagonist toxicity.
- William Kerns.
- Division of Toxicology, Department of Emergency Medicine, Carolinas Medical Center, Medical Education Building, Charlotte, NC 28203, USA. rkerns@carolinashealthcare.org
- Emerg. Med. Clin. North Am. 2007 May 1; 25 (2): 309-31; abstract viii.
AbstractState-of-the-art therapy for beta-adrenergic receptor blocker and calcium channel antagonist toxicity is reviewed in the light of new insights into drug-induced shock. A brief discussion of pathophysiology, including cardiac, hemodynamic, and metabolic effects of cardiac drug toxicity, provides a foundation for understanding the basis of therapy. The major focus of this review is a critical evaluation of antidotal use of calcium, glucagon, catecholamines, insulin-euglycemia, and other novel therapies based on investigational studies and cumulative clinical experience.
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