• Akiyoshi Hagiwara, Akio Kimura, Hiroshi Kato, Yasuaki Mizushima, Tetsuya Matsuoka, Munekazu Takeda, Toshifumi Uejima, Yusuke Hagiwara, Yuichiro Sakamoto, Daisuke Kudo, and Junichi Sasaki.
• Department of Traumatology and Critical Care Medicine, National Defense Medical College, Japan. ahagiwar@imcj.hosp.go.jp
• J Trauma. 2010 Nov 1;69(5):1161-8.

ObjectThis study sought to define hemorrhagic shock from blood pressure and heart rate and then to provide a treatment policy based on response to initial fluid therapy.MaterialsThis was a prospective clinical observational study conducted in eight hospitals. Subjects were consecutive patients with trauma who met any of the field triage conditions proposed by the Committee on Trauma of the American College of Surgeons. Initial fluid therapy was performed in patients with suspected hemorrhagic shock. Patients who required blood transfusion ≥ 4 U within 24 hours or interventions for active bleeding within 24 hours were classified into a "bleeding group" (B). A "nonbleeding group" (non-B) comprised patients who did not require blood transfusion ≥ 4 U or other interventions within 24 hours. Our committee maintained the database of survey items. Four of the hospitals were selected at random to provide training data and that was used in a recursive partitioning analysis to predict the B group. Data on patients in the other four facilities were used for validation.ResultsThere were a total of 400 patients studied. The training set consisted of 261 patients, 50 of whom were classified into the B group. A total of 94% patients with hemorrhagic shock suspected clinically, shock index at admission (first SI) ≥ 0.8, and SI at 1 L of fluid resuscitation (second SI) ≥ 1.0 were assigned to the B group. The non-B group (92%) were patients those whose first SI was < 0.8 and base deficits at admission ≥ -1.0. Validation data consisted of 139 patients. The sensitivity, specificity, and accuracy of these data to predict the B group were 71%, 93%, and 89%, respectively.ConclusionsPatients whose first SI was ≥ 0.8 and second SI ≥ 1.0 would be diagnosed as "nonresponders" by American College of Surgeons. Patients with first SI < 0.8 and base deficits ≥ -1.0 will not be candidates for the B group.

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