• Acta medica Scandinavica · Jan 1977

    Randomized Controlled Trial Comparative Study Clinical Trial Controlled Clinical Trial

    Prostaglandin-induced diarrhoea treated with loperamide or diphenoxylate. A double-blind study.

    • A P Lange, N J Secher, and W Amery.
    • Acta Med Scand. 1977 Jan 1; 202 (6): 449-54.

    AbstractLoperamide was compared double-blind with diphenoxylate and a placebo in 59 women with diarrhoea due to prostaglandin administration for mid-trimester abortion. Treatment was started with the intake of two capsules two hours before the first intramuscular injection of 15(S-)15 methyl prostaglandin F2alpha and was then adapted individually, i.e. one capsule after each unformed stool, with a maximum of ten per 24 hours. Both antidiarrhoeals were significantly more effective than the placebo in preventing diarrhoea, and loperamide was found to be more active than diphenoxylate. The course of abortion, BP and vital signs, or prostaglandin side-effects other than diarrhoea were not affected by either antidiarrhoeal, nor could any adverse experience be specifically attributed to them.

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