• Transplant. Proc. · Nov 2015

    Case Reports

    Is There a Role for Desmopressin in Liver Transplantation? A Case Report.

    • M M Gonzales, D Z Valdes, R Helmick, T Taner, and G Vasdev.
    • Department of Surgery, Division of Transplantation Surgery, Mayo Clinic, Rochester, Minnesota, United States.
    • Transplant. Proc. 2015 Nov 1; 47 (9): 2782-5.

    AbstractLiving donor liver transplantation reduces time and mortality on the waiting list. Bleeding is a serious complication; however, "overcorrection" of coagulopathy may lead to hepatic artery thrombosis. We report a case where desmopressin (DDAVP) was used in the management of persistent postreperfusion bleeding (44 red blood cell units transfused). After 1 dose of DDAVP, bleeding improved significantly and the recipient had an unremarkable recovery. DDAVP should be considered for persisting bleeding after correcting common coagulation abnormalities where complexity of the anastomosis may preclude the use of more aggressive procoagulant drugs in liver transplantation. Copyright © 2015 Elsevier Inc. All rights reserved.

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