• Mauricio Guivernau and Miguel Berr.
• Programa de Farmacología Molecular y Clínica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile. mguivern@med.uchile.cl
• Rev Med Chil. 2008 Jul 1; 136 (7): 823-30.

BackgroundMyocardial revascularization surgery has used several vessels as coronary grafts including internal mammary and radial arteries which have a better prognosis than saphenous vein. Their long-term patency has been associated with the release of endothelium vasodilator and anti-aggregating products such as prostacyclin. Diabetes induces endothelial dysfunction and a high number of diabetics require revascularization.AimTo assess the capacity to synthesize prostacyclin of different vessels from diabetics.Material And MethodsInternal mammary and radial arteries and saphenous veins obtained from 10 diabetic and 10 non diabetic patients subjected to coronary artery bypass surgery were studied. The capacity to synthesize prostacyclin was assessed in these vessels measuring its hydrolysis product, the 6-keto-PGFla by radioimmunoassay.ResultsInternal mammary arteries and saphenous veins from diabetics synthesized a lower amount of prostacyclin than those from non-diabetics. The radial artery produced similar amounts of prostacyclin in both groups. This response was associated with an increase of the conversion of the precursor arachidonic acid to prostacyclin. The saturating concentrations of this acid required to achieve the maximal stimulation were higher in the radial artery (20 microM) than in the internal mammary artery and saphenous vein (10 microM), suggesting that the enzymatic activity of the radial artery was not affected by diabetes.ConclusionsThe radial artery appears as the best replacement vessel for coronary surgery in diabetics. Its favorable biochemical profile and potential lower long-term occlusion rate may be relevant for a better prognosis of myocardial revascularization in these patients.

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