• Int. J. Tuberc. Lung Dis. · Feb 2013

    Review

    Compassionate use of and expanded access to new drugs for drug-resistant tuberculosis.

    • C R Horsburgh, M Haxaire-Theeuwes, C Lienhardt, C Wingfield, D McNeeley, L Pyne-Mercier, S Keshavjee, F Varaine, Research Excellence to Stop TB Resistance (RESIST-TB), and Critical Path to TB Drug Regimens' Access and Appropriate Use Workgroup.
    • Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts 02118, USA. rhorsbu@bu.edu
    • Int. J. Tuberc. Lung Dis. 2013 Feb 1;17(2):146-52.

    AbstractSeveral new classes of anti-tuberculosis agents are likely to become available in the coming decade. Ensuring prompt access to these drugs for patients without other treatment options is an important medical and public health issue. This article reviews the current state of 'compassionate use' and 'expanded access' programs for these new drugs, and identifies several shortcomings that will limit patient access to the drugs. A series of five steps is outlined that will need to be taken by national health bodies, international agencies and non-governmental organizations to prevent undue delays in access to new tuberculosis drugs for patients who could benefit from them. Following these steps can ensure that patients will be able to benefit from access to these drugs, while minimizing the risk of emergence of resistance to the drug.

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