• Itamar S Santos, Alessandra C Goulart, Valeria M Passos, Maria del Carmen Molina, Paulo A Lotufo, and Isabela M Bensenor.
• Faculdade de Medicina da Universidade de São Paulo, Brazil Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário da Universidade de São Paulo, Brazil itamarss@usp.br.
• Cephalalgia. 2015 Apr 1; 35 (5): 426-36.

Background And AimMost studies assessing the association between migraine and obesity have shown conflicting results. We aimed to evaluate the association between obesity and migraine in ELSA-Brasil, a cohort study of 15,105 individuals aged 35-74 years.MethodsWe assessed migraine using a validated questionnaire based on International Headache Society criteria and anthropometric measurements using standard techniques. Migraine was categorized as daily and non-daily. World Health Organization criteria were used to categorize overweight, obesity and abdominal obesity (AbO). We performed a cross-sectional analysis using multivariate logistic regression models to study the association between migraine and obesity (body mass index (BMI) ≥ 30 kg/m(2)), compared to controls without migraine.ResultsWe found an association between daily migraine and obesity (odds ratio (OR) 1.86; 95% confidence interval (95% CI): 1.12-3.09). Although the presence of AbO was not associated with migraine, interaction models showed that the association between obesity and daily migraine remained strong only in the absence of AbO diagnosis, notably in individuals aged 35-49 years.DiscussionIn our large sample of individuals aged 35 years or older, obesity, but not AbO, was associated with daily migraine. AbO influenced the association between BMI and daily migraine in migraineurs aged 35-49 years.© International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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