• K M Dolman, F B Plötz, T F W Wolfs, J H J Beunders, and A J van Vught.
• Afd. Algemene Pediatrie, Universitair Medisch Centrum, locatie Wilhelmina Kinderziekenhuis, Utrecht. k.m.dolman@amc.uva.nl
• Ned Tijdschr Geneeskd. 2002 Apr 6;146(14):668-71.

AbstractA 4-year-old girl developed tetanus after she had fallen on the street a week before. She had never been vaccinated and despite pressure from the family practitioner, the parents refused to allow her to be given human anti-tetanus immunoglobulin as a matter of principle after the wound had been stitched. Seven days later she was admitted to hospital with trismus and risus sardonicus. Upon initial treatment with human anti-tetanus immunoglobulin and penicillin, and subsequently metronidazole, her clinical condition deteriorated with opisthotonus and life-threatening respiratory insufficiency, upon which she was moved to the intensive-care department where she was intubated and mechanically ventilated for two weeks. Finally she made a complete clinical recovery. Thanks to the extensive national vaccination program, tetanus has become a rare disease in the Netherlands. However, the very serious course and possible fatal outcome warrant a keen attitude and adequate treatment.

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