• Rupendra Shrestha, Reena Shrestha, Ram Bahadur Khadka, and Rabin Gyawali.
• Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, New York, United States.
• JNMA J Nepal Med Assoc. 2021 Jul 30; 59 (239): 727-729.

AbstractWhile there is absolutely no evidence to ensure recovered patients are either likely or unlikely to get reinfected. But studies in non-human primates indicate that reinfection of recovered patients is highly unlikely. It is also clear that primary immune responses or induced immunity to severe acute respiratory syndrome coronavirus 2 remain in circulation for several months and at least temporarily confer immunity to protect from reinfection. In addition, negative virus culture analysis of re-positive suggests that positive reverse transcriptase-polymerase chain reactions in recovered patients are more likely to be false-positive, or detection of genetic remnants of virus discharged from lesions of lungs or better sampling at the time of repeat analysis. However, emerging severe acute respiratory syndrome coronavirus 2 variants are likely to be causing the infections observed in some of the recovered patients.

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