• MMW Fortschr Med · Dec 2017

    [Therapeutic modulation of intestinal microbiota in irritable bowel syndrome. From probiotics to fecal microbiota therapy].

    • P C Konturek and Yurdagül Zopf.
    • Klinik für Innere Medizin II, Thüringen-Kliniken GmbH Saalfeld, Rainweg 68, 07318, Saalfeld, Deutschland. pkonturek@web.de.
    • MMW Fortschr Med. 2017 Dec 1; 159 (Suppl 7): 1-5.

    BackgroundAn abnormal intestinal microbiota (dysbiosis) plays a central role in the pathogenesis of the irritable bowel syndrome.MethodAn overview of four current options for the treatment of irritable bowel syndrome, which are characterized by modulation of intestinal microbiota, is given.Results And ConclusionsProbiotics have very different effects on the individual symptoms of the irritable bowel. The choice of the appropriate preparation should therefore be based on the clinical symptomatology. The antibiotic rifaximin is effective in selected patients. Some patients also benefit from the repetition of this therapy. A FODMAP-reduced diet has shown significant alleviation of irritable bowel symptoms in studies. The fecal microbiota therapy (FMT) is a promising treatment option. At present, however, there are no such placebo-controlled studies to assess the effectiveness of this method.

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