• Clin. Chim. Acta · Jan 2014

    Review

    Apelin and its receptor APJ in cardiovascular diseases.

    • Xiao-Hua Yu, Zhi-Bin Tang, Li-Jing Liu, Hong Qian, Shi-Lin Tang, Da-Wei Zhang, Guo-Ping Tian, and Chao-Ke Tang.
    • Life Science Research Center, University of South China, Hengyang, Hunan 421001, China.
    • Clin. Chim. Acta. 2014 Jan 20; 428: 1-8.

    AbstractApelin is an adipokine that has been identified as an endogenous ligand for the orphan receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular preponderance for the heart and vasculature. Apelin has powerful positive inotropic actions and causes endothelium- and nitric oxide-dependent vasodilatation. Growing evidence shows that apelin/APJ system functions as a critical mediator of cardiovascular homeostasis and is involved in the pathophysiology of cardiovascular diseases. Targeting apelin/APJ axis produces protection against cardiovascular diseases. In the current review we have summarized recent data concerning the role and therapeutic potential of apelin/APJ in several major cardiovascular diseases. An increased understanding of the cardiovascular actions of apelin/APJ system will help to develop novel therapeutic interventions for cardiovascular diseases. © 2013. Elsevier B.V. All rights reserved.

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