• W Wang, W Yang, and S T Micha.
• Department of Infectious Diseases, Dongguan People's Hospital, Dongguan, Guandong 523000, China. Pwangwen@pub.dgnet.gd.cn
• Chinese Med J Peking. 2001 Jun 1; 114 (6): 612-3.

ObjectiveTo evaluate the clinical efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria.MethodsFifty-four patients with symptomatic falciparum malaria were allocated to receive oral dihydroartemisinin at a single dose of 120 mg on day 1, followed by mefioquine, 750 mg and 500 mg on days 2 and 3, respectively. Follow-up was performed on days 1, 2, 3, 4, 7, 14, 21, and 28.ResultsAll patients had a rapid initial response to treatment. The parasite clearance time (PCT) after treatment was 30.7 +/- 3.6 hours. The fever subsidence time (FST) after treatment was 21.2 +/- 2.8 hours. Two patients had a recrudescence 21 and 25 days respectively after the disappearance of parasitemia, hence the recrudescence rate was 3.7% and the cure rate was 96.3%. No serious adverse effects were observed, only mild and transient nausea, vomiting and loss of appetite.ConclusionA combination of dihydroartemisinin and mefloquine is effective in the treatment of acute uncomplicated falciparum malaria.

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