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Case Reports
A Case of Duloxetine-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Super-elderly Patient.
- Toru Hamada, Katsuyuki Matsuki, Seiji Kondou, Shinya Furukawa, and Morikazu Onji.
- Department of Internal Medicine, National Health Insurance Kuma-Kogen Town Hospital, Japan.
- Intern. Med. 2022 Apr 1; 61 (7): 1099-1103.
AbstractDuloxetine is widely used for pain control and depressive syndromes. One of its potential side effects is syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Duloxetine-induced SIADH causes hyponatremia, which leads to a variety of symptoms and has previously been reported in the elderly. In the present case, we experienced a case of the rapid onset of SIADH in a super-elderly woman receiving low-dose duloxetine. Elderly patients tend to have lower duloxetine doses and an earlier onset than non-elderly patients. When hyponatremia occurs after duloxetine administration, duloxetine-induced SIADH should be considered, especially in high-risk elderly patients, regardless of the duloxetine dose or duration of treatment.
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