• Carmela Bou Malham, Sarah El Khatib, Philippe Cestac, Sandrine Andrieu, Laure Rouch, and Pascale Salameh.
• Center for Epidemiology and Research in POPulation Health (CERPOP), Université de Toulouse, Inserm, Université Paul Sabatier, Toulouse, France.
• Int. J. Clin. Pract. 2021 Nov 1; 75 (11): e14864.

BackgroundIn an era of rapid evolution in healthcare delivery, major changes have occurred within the profession of pharmacist. Because the impact of pharmacist-led interventions in the hospital setting has been well-studied and showed mixed findings on drug-related readmissions, all-cause emergency department visits and mortality, this systematic review focused on services provided by pharmacists in the community or ambulatory care setting without being limited to a specific intervention or outcome.ObjectiveTo investigate the impact of pharmacist-led interventions, categorised into clinical medication review (CMR), adherence review (AR), and prescription review (PR) on various aspects of patient care (clinical, behavioural, economic and humanistic outcomes in ambulatory care setting) and understand which particular intervention makes the greatest contribution.MethodsA literature search was conducted using MEDLINE, Embase and the Cochrane Library for publications from 2000 onwards.Findings And InterpretationA total of 31 relevant publications corresponding to 27 controlled trials (CTs) and 4 observational studies were selected. CMR was the most studied pharmacist-led intervention (n = 19, 61.29%), followed by AR (n = 6, 19.3%). CMR demonstrated a favourable effect on different clinical outcomes mainly the management of drug-related problems and adverse events, and it also contributed the most to the reduction of healthcare costs. AR was the most effective intervention to improve patient's adherence. CMR alone or combined with AR both raised equally the patient's satisfaction.ConclusionOur results showed that CMR can play a major role in the management of drug-related problems and economic issues. AR can significantly improve patient compliance. Larger, standardised and rigorously designed intervention studies are needed to help decision-makers to select appropriate interventions leading to meaningful improvements in patient care.© 2021 John Wiley & Sons Ltd.

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