• Pierfranco Terrosu, Alessandro Boccanelli, Giuseppe Sabino, Paolo Alboni, Samuele Baldasseroni, Mario Bo, Giovambattista Desideri, Niccolò Marchionni, Giuseppe Palazzo, Renzo Rozzini, Andrea Ungar, Francesco Vetta, and Giovanni Zito.
• SICGe - Società Italiana di Cardiologia Geriatrica, Florence, Italy - pterrosu@hotmail.com.
• Minerva Med. 2022 Aug 1; 113 (4): 640-646.

AbstractRecently, transcatheter aortic valve replacement (TAVR) has emerged as established standard treatment for symptomatic severe aortic stenosis, providing an effective, less-invasive alternative to open cardiac surgery for inoperable or high-risk older patients. In order to assess the anticipated benefit of aortic replacement, considerable interest now lies in better identifying factors likely to predict outcome. In the elderly population frailty and medical comorbidities have been shown to significantly predict mortality, functional recovery and quality of life after transcatheter aortic valve replacement. Scientific literature focused on the three items will be discussed. High likelihood of futility is described in patients with severe chronic lung, kidney, liver disease and/or frailty. The addition of frailty components to conventional risk prediction has been shown to result in improved discrimination for death and disability following the procedure and identifies those individuals least likely to derive benefit. Several dedicated risk score have been proposed to provide new insights into predicted "futile" outcome. However, assessment of frailty according to a limited number of variables is not sufficient, while a multi-dimensional geriatric assessment significantly improves risk prediction. A multidisciplinary heart team that includes geriatricians can allow the customization of therapeutic interventions in elderly patients to optimise care and avoid futility.

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