• Der Anaesthesist · Sep 2021

    Effects of 5 µg/kg intrathecal morphine for postoperative analgesia in pediatric patients undergoing major surgery.

    • Gülsen Keskin, Mine Akın, Yeşim Şenaylı, Can İhsan Öztorun, and Melike Bahçecitapar.
    • Clinic of Anesthesiology and Reanimation, Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital, Üniversiteler mah. 1598 sok. Kümeevleri 17/22, 06800, Ankara, Turkey. drgulsenkeskin@gmail.com.
    • Anaesthesist. 2021 Sep 21.

    BackgroundThe effects and analgesic adequacy of intrathecal morphine (ITM) administration have been studied less frequently than other regional analgesia techniques in pediatric surgical procedures.ObjectiveTo evaluate the efficacy and adverse event rate of 5 µg/kg ITM administration for postoperative analgesia according to age group.MethodsWe retrospectively evaluated the medical records of patients who underwent major pediatric surgery and were administered ITM for postoperative analgesia. Patients were divided into three age groups: ≤ 5 years (group I), 5.1-13 years (group II) and > 13 years (group III). All patients received ITM 5 µg/kg (max 300 μg) through the L4-5 or L5-S1 interspace. Postoperative pain (modified pediatric objective pain score > 4), need for rescue analgesics, sleep interruption due to pain, sedation (Ramsay sedation scale score > 3), opioid-related postoperative adverse events (at 0, 4, 8, 12, and 24 h after intervention), hemodynamic data and nurse satisfaction with the analgesic method were compared between groups.ResultsThe analysis included 100 children (47 girls, 9 ± 5.4 years). Groups were similar regarding postoperative rescue analgesia consumption and sleep interruption (p = 0.238, p = 0.958), 96% of the children did not require rescue analgesia, and sleep interruption was not observed in 97%. Postoperative adverse events were pruritus in 14 and nausea/vomiting in 9 patients (p = 0.052). Overall, nurses were satisfied or very satisfied in 99% of the cases.ConclusionAdministration of 5 µg/kg ITM can be used for postoperative analgesia in pediatric surgery in all age groups, with no severe adverse events and high nurse satisfaction with analgesic management.© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

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