• Clinical therapeutics · Sep 1991

    Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial

    Randomized comparison of cefotaxime and ceftriaxone in patients with uncomplicated gonorrhea.

    • R B Jones, W J Mogabgab, W M McCormack, and G D Wendel.
    • Indiana University School of Medicine, Indianapolis.
    • Clin Ther. 1991 Sep 1; 13 (5): 550-6.

    AbstractCefotaxime is a third-generation cephalosporin with excellent in vitro antimicrobial activity against Neisseria gonorrhoeae, including beta-lactamase-producing strains. A single, 1-gm, intramuscular dose has previously been shown to be effective in the treatment of uncomplicated gonorrhea. A randomized, multicenter study was conducted to evaluate the efficacy and safety of a lower, 500-mg dose of cefotaxime in comparison with ceftriaxone 250 mg, the standard treatment for uncomplicated gonorrhea. One hundred forty-two patients were enrolled and 115 were evaluable. Bacteriologic eradication rates were 95% in the cefotaxime group and 100% in the ceftriaxone group (P = 0.119). Adverse events that were possibly related to the study drug occurred in 3% and 8% of patients in the cefotaxime and ceftriaxone groups, respectively. Cefotaxime 500 mg appears to be a safe and cost-effective alternative to ceftriaxone 250 mg for the treatment of uncomplicated gonorrhea.

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