• Drug discovery today · Aug 2020

    Review

    Discovering small-molecule therapeutics against SARS-CoV-2.

    • Vaibhav Tiwari, Jacob C Beer, Nehru Viji Sankaranarayanan, Michelle Swanson-Mungerson, and Umesh R Desai.
    • Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University Downers Grove, IL 6051, USA; Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA. Electronic address: vtiwar@midwestern.edu.
    • Drug Discov. Today. 2020 Aug 1; 25 (8): 1535-1544.

    AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly become a global health pandemic. The lack of effective treatments, coupled with its etiology, has resulted in more than 400,000 deaths at the time of writing. The SARS-CoV-2 genome is highly homologous to that of SARS-CoV, the causative agent behind the 2003 SARS outbreak. Based on prior reports, clinicians have pursued the off-label use of several antiviral drugs, while the scientific community has responded by seeking agents against traditional targets, especially viral proteases. However, several avenues remain unexplored, including disrupting E and M protein oligomerization, outcompeting host glycan-virus interactions, interfering with the heparan sulfate proteoglycans-virus interaction, and others. In this review, we highlight some of these opportunities while summarizing the drugs currently in use against coronavirus 2019 (COVID-19).Copyright © 2020 Elsevier Ltd. All rights reserved.

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