• Current HIV research · Jan 2011

    HIV infection induces morphometrical changes on the oral (buccal mucosa and tongue) epithelial cells.

    • Adriane Bastos Pompermayer, Francisca Berenice Dias Gil, Beatriz Helena Sottile França, Maria Ângela Naval Machado, Paula Cristina Trevilatto, Angela Fernandes, and de LimaAntônio Adilson SoaresAA.
    • Department of Stomatology, School of Dentistry, Pontifícia Universidade Católica do Paraná, Brazil.
    • Curr. HIV Res. 2011 Jan 1; 9 (1): 11-6.

    AbstractThe aim of this study was to assess morphological and morphometrical alterations of oral squamous epithelial cells in type 1 HIV infected individuals. Oral smears were collected from tongue and buccal mucosa of 30 HIV infected (experimental) and 30 non-infected (control) individuals by liquid-based exfoliative cytology. The cells were morphologically analyzed and the nuclear area (NA), the cytoplasmic area (CA) and the nucleus-to-cytoplasm area ratio (NA/CA) were calculated. No morphological differences were found between the groups. The mean values of CA were decreased in tongue (P=.00006) and buccal mucosa (P=.00242) in HIV infected individual, while mean values of NA were increased (P=.00308 and .00095, respectively) in the same group. NA/CA ratio for experimental group was increased in both collected places, with P=.00001 (tongue) and P=.00000 (buccal mucosa). This study revealed that HIV infection was able to induce morphometrical changes on the oral epithelial cells.

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