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Multicenter Study Observational Study
Association between sleep disordered breathing and aggressiveness markers of malignant cutaneous melanoma.
- Miguel-Ángel Martínez-García, Antonio Martorell-Calatayud, Eduardo Nagore, Irene Valero, Maria Jose Selma, Eusebi Chiner, Pedro Landete, Josep-Maria Montserrat, Cristina Carrera, Amalia Pérez-Gil, Francisco Campos-Rodríguez, and Ramón Farré.
- Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia CIBER de Enfermedades Respiratorias, Bunyoles mianmartinezgarcia@gmail.com.
- Eur. Respir. J. 2014 Jun 1; 43 (6): 1661-8.
AbstractSome recent studies have shown an association between sleep disordered breathing (SDB) and cancer mortality and incidence but no study has focused on a specific type of cancer. The objective of this study was to analyse the relationship between the severity of SDB and factors related to cutaneous malignant melanoma (CMM) aggressiveness. We performed a multicentre observational study in 82 consecutive patients diagnosed with CMM. 56 patients in whom melanoma measurements were available were finally included in the study. Melanoma measurements of aggressiveness included: tumour mitotic rate, Breslow index, presence of ulceration, stage of disease and growth rate of melanoma. A sleep study was performed in all the included patients. Multivariate analyses were used to examine the independent relationship between SDB severity (apnoea-hypopnea index (AHI) and nocturnal oxygen desaturation indexes (ODI3% and ODI4%)) and measures of CMM aggressiveness. 60.7% of patients had SDB (AHI ≥ 5) and 14.3% severe obstructive sleep apnoea (AHI ≥ 30). In fully adjusted multivariate analyses, AHI (OR 1.08, 95% CI 1.02-1.14), ODI3% (OR 1.08, 95% CI 1.02-1.11) and ODI4% (OR 1.1, 95% CI 1.02-1.2) were independently associated with an increased melanoma growth rate. Furthermore, AHI, ODI4% and ODI3% were significantly correlated with other aggressiveness factors of CMM, such as Breslow index, presence of ulceration and mitotic index. SDB severity markers are associated with some aggressiveness markers of CMM.©ERS 2014.
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