• Military medicine · Oct 2022

    Case Reports

    Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism.

    • Jana W Qiao, Yongwook Dan, Michael E Wolf, Christina M Zoccoli, Theodore J Demetriou, and Robert P Lennon.
    • Department of Family and Community Medicine, Penn State Health Milton S. Hershey, Hershey, PA, USA.
    • Mil Med. 2022 Oct 29; 187 (11-12): e1480e1482e1480-e1482.

    AbstractCoronavirus disease (COVID) toes are pernio-like skin lesions associated with severe acute respiratory syndrome coronavirus 2. We observed pernio-like skin findings presenting after a Pfizer BioNTech vaccine, which significantly worsened after an infusion of rituximab. This suggests that the mechanism for COVID toes is interferon activation. Military providers may avoid unnecessary referrals for this self-limiting condition by anticipating this adverse effect.© The Association of Military Surgeons of the United States 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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