• Pouya Youssefi, David Timbrell, Oswaldo Valencia, Peter Gregory, Caterina Vlachou, Marjan Jahangiri, and Mark Edsell.
• Department of Cardiothoracic Surgery, St. George's Healthcare NHS Trust, London, United Kingdom. Electronic address: pyyoussefi@aol.com.
• J. Cardiothorac. Vasc. Anesth. 2015 Dec 1; 29 (6): 1466-71.

ObjectivesFast-track (FT) management of cardiac surgery patients is associated with early extubation and reduced length of intensive care unit (ICU) stay, with potential benefit of reduced hospital costs. The authors examined perioperative factors and their influence on failure of FT and what implications this failure had.DesignProspective data collection from all adult cardiac surgeries between 2011 and 2013.SettingSingle-institution study.ParticipantsThe study included 2,770 consecutive adult cardiac surgery patients.InterventionsAll participants underwent adult cardiac surgeries. Of those, 451 (16.3%) patients were selected to undergo FT management.Measurements And Main ResultsFailure of FT was defined as early (admission to ICU on day of surgery) or late (patients later admitted to the ICU from the ward). Univariate and multivariate regression analyses were used to identify which variables predicted FT failure. Of the 451 patients included in this study, 138 (30.6%) failed the FT, with 115 (83.3%) early failures and 23 (16.7%) late failures. Predictors of failure were reduced renal function, hypertension, age, EuroSCORE, cardiopulmonary bypass time, first lactate or base deficit after surgery (all p<0.01), and cross-clamp time (p<0.05). Multivariate analysis showed that the strongest predictor of failure was glomerular filtration rate (GFR)<65 mL/min/BSA (sensitivity, 54%; specificity, 61%; likelihood ratio, 1.39; area under receiver operating characteristics curve, 0.59; 95% confidence interval, 0.53-0.64). Median length of hospital stay was longer for the failed group (5 v 7 days, p<0.001). There were no mortalities in any of the patients selected for FT.ConclusionsA number of perioperative factors are associated with failure to FT, the strongest predictor being GFR. Failure to FT can lead to significantly longer hospital stay.Copyright © 2015 Elsevier Inc. All rights reserved.

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