• W T Pochis, A Z Krasnow, B D Collier, M W Mewissen, U A Almagro, R S Hellman, and A T Isitman.
• Department of Radiology, Medical College of Wisconsin, Milwaukee.
• Clin Nucl Med. 1990 May 1; 15 (5): 321-3.

AbstractA case of idiopathic pulmonary fibrosis with multiple areas of mismatch on ventilation-perfusion lung imaging in the absence of pulmonary embolism is presented. Idiopathic pulmonary fibrosis is one of the few nonembolic diseases producing a pulmonary ventilation-perfusion mismatch. In this condition, chest radiographs may not detect the full extent of disease, and xenon-133 ventilation imaging may be relatively insensitive to morbid changes in small airways. Thus, when examining patients with idiopathic pulmonary fibrosis, one should be aware that abnormal perfusion imaging patterns without matching ventilation abnormalities are not always due to embolism. In this setting, contrast pulmonary angiography is often needed for accurate differential diagnosis.

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