• Am J Phys Med Rehabil · Nov 2002

    Review

    Role of fatigue in limiting physical activities in humans with neuromuscular diseases.

    • Robert G Miller.
    • Department of Neurology, California Pacific Medical Center, San Francisco, California 94115, USA.
    • Am J Phys Med Rehabil. 2002 Nov 1; 81 (11 Suppl): S99-107.

    AbstractNew methods of examining both central and peripheral fatigue are now available. A broader understanding of the mechanisms of fatigue in healthy human subjects has begun to emerge. The mechanisms of fatigue in patients with various neuromuscular diseases are even more complex than in healthy persons. Examples of both central and peripheral fatigue in various neuromuscular diseases and other disorders are presented, including metabolic myopathy, chronic fatigue syndrome, postpolio syndrome, and amyotrophic lateral sclerosis.

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