• Toxicology letters · Apr 2004

    Review Historical Article

    Generally recognized as safe (GRAS): history and description.

    • George A Burdock and Ioana G Carabin.
    • Burdock Group, 888, 17th Street, NW, Suite 810, Washington, DC 20006, USA. gburdock@burdockgroup.com
    • Toxicol. Lett. 2004 Apr 15; 150 (1): 3-18.

    AbstractGenerally recognized as safe (GRAS), a system for review and approval of ingredients for addition to food, was conceived at a time when the need for a less doctrinaire review of food ingredients was critical. The GRAS approval process for a food ingredient relies on the judgment of "...experts qualified by scientific training and experience to evaluate its safety..." the end product of which is no better or worse than that by FDA, but often more expeditious. The process and requirements for a successful GRAS determination are discussed and compared with that of the food additive petition (FAP) process. The future of the GRAS process is assured by its history of successful performance, bringing safe food ingredients to the consumer in a timely manner.

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