• Internal medicine · Apr 2022

    Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease.

    • Yuki Hiroshima, Keijiro Sato, Toshimitsu Ueki, Masahiko Sumi, Mayumi Ueno, Naoaki Ichikawa, Hidetoshi Satomi, and Hikaru Kobayashi.
    • The Department of Hematology, Nagano Red Cross Hospital, Japan.
    • Intern. Med. 2022 Apr 15; 61 (8): 1225-1230.

    AbstractTwo adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD.

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