• Matthew R Nichols, Jeremy T Gaskins, Daniel S Metzinger, Sarah L Todd, Harriet B Eldredge-Hindy, and Scott R Silva.
• From the Departments of Gynecologic Oncology and Radiation Oncology, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, the Department of Bioinformatics & Biostatistics, University of Louisville School of Public Health and Information Sciences, Louisville, Kentucky, and the Department of Radiation Oncology, Medical University of South Carolina, Charleston.
• South. Med. J. 2021 Oct 1; 114 (10): 630-635.

ObjectivesThe objective of this analysis was to gauge how the incidence and mortality of uterine cancer in Kentucky have changed from 1995 through 2017. An assessment of the trends in incidence and mortality across different geographic areas and between different races was also performed.MethodsAge-adjusted annual incidence and mortality rates for uterine cancer were obtained from the Kentucky Cancer Registry. A meta-regression framework was used to assess changes in incidence and mortality rates during the time frame and to determine differences in these rates between rural versus urban counties, Appalachian versus non-Appalachian counties, and Black versus White women.ResultsThe incidence of uterine cancer has significantly increased throughout the state of Kentucky since 1995. Uterine cancer incidence was 10% and 22% higher in rural and Appalachian counties, respectively, compared with urban and non-Appalachian counties (P < 0.0001) from 1995 through 2017. In contrast, urban and non-Appalachian women had higher or equivalent age-adjusted mortality from uterine cancer, compared with rural and Appalachian women, respectively. The incidence of uterine cancer was significantly higher in White women compared with Black women from 1995 through 2006, but since 2007, there has been no significant difference in uterine cancer incidence based on race. Black women had higher age-adjusted mortality than White women throughout the entire time period examined.ConclusionsThe incidence of uterine cancer is higher in rural and Appalachian Kentucky, without a corresponding geographic trend in mortality. Uterine cancer mortality is significantly higher in Black women.

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