• Brett K Beaulieu-Jones, Zhiwei Steven Wu, Chris Williams, Ran Lee, Sanjeev P Bhavnani, James Brian Byrd, and Casey S Greene.
• Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia. (B.K.B.-J.).
• Circ Cardiovasc Qual. 2019 Jul 1; 12 (7): e005122.

BackgroundData sharing accelerates scientific progress but sharing individual-level data while preserving patient privacy presents a barrier.Methods And ResultsUsing pairs of deep neural networks, we generated simulated, synthetic participants that closely resemble participants of the SPRINT trial (Systolic Blood Pressure Trial). We showed that such paired networks can be trained with differential privacy, a formal privacy framework that limits the likelihood that queries of the synthetic participants' data could identify a real a participant in the trial. Machine learning predictors built on the synthetic population generalize to the original data set. This finding suggests that the synthetic data can be shared with others, enabling them to perform hypothesis-generating analyses as though they had the original trial data.ConclusionsDeep neural networks that generate synthetic participants facilitate secondary analyses and reproducible investigation of clinical data sets by enhancing data sharing while preserving participant privacy.

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