• Bo Xu, Tian Liu, Pascal Spincemaille, Martin Prince, and Yi Wang.
• Department of Radiology, Weill Cornell Medical College, New York, New York, USA; Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
• Magn Reson Med. 2014 Aug 1; 72 (2): 438-45.

PurposeVenous blood oxygen saturation is an indicator of brain oxygen consumption and can be measured directly from quantitative susceptibility mapping (QSM) by deconvolving the MR phase signal. However, accurate estimation of the susceptibility of blood may be affected by flow induced phase in the presence of imaging gradient and the inhomogeneous susceptibility field gradient. The purpose of this study is to correct the flow induced error in QSM for improved venous oxygenation quantification.MethodsFlow compensation is proposed for QSM by using a fully flow compensated multi-echo gradient echo sequence for data acquisition. A quadratic fit of the phase with respect to echo time is employed for the flow phase in the presence of inhomogeneity field gradients. Phantom and in vivo experiments were carried out to validate the proposed method.ResultsPhantom experiments demonstrated reduced error in the estimated field map and susceptibility map. Initial data in in vivo human imaging demonstrated improvements in the quantitative susceptibility map and in the estimated venous oxygen saturation values.ConclusionFlow compensated multi-echo acquisition and an adaptive-quadratic fit of the phase images improves the quantitative susceptibility map of blood flow. The improved vein susceptibility enables in vivo measurement of venous oxygen saturation throughout the brain.Copyright © 2013 Wiley Periodicals, Inc.

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