• Ying Feng, Jin-Yu Peng, and Zhiyong Peng.
• Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Center of Critical Care Clinical Research of Hubei Province, Wuhan.
• Curr Opin Crit Care. 2021 Dec 1; 27 (6): 582-586.

Purpose Of ReviewSepsis and septic shock are life-threatening diseases with high mortality. Although efforts have made to improve the survivals, the outcomes are still frustrating. Blood purification was thought to be a promising adjunctive therapy to regulate the excessive cytokine storm or to reduce the endotoxin activity caused by sepsis. Critically ill COVID-19 characterized with the similar disease to sepsis may also benefit from blood purification.Recent FindingsThe recent studies mainly focused on hemadsorption materials. The results of the clinical trials showed a tendency in decrease of cytokine levels and endotoxin activity and improvement in haemodynamics. However, the results were controversial. More evidence about blood purification in sepsis and COVID-19 are needed from currently ongoing trials and future well designed trials.SummaryThe blood purification therapy demonstrated the tendency in decrease of cytokines and endotoxin activity in different degree according to the current studies. However, the effect on mortality and haemodynamics is still in controversy. Further well designed, large sample sized studies should focus on the timing of initiating blood purification, the appropriate indications and the optimal type of blood purification membrane or cartridge to provide more evidence for clinical practice.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

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