• J Am Soc Echocardiogr · Nov 2009

    Health-e-Child project: mechanical dyssynchrony in children with dilated cardiomyopathy.

    • Fabien Labombarda, Julie Blanc, Arnaud Pellissier, Bertrand Stos, Cathy Gaillard, Fanny Bajolle, Alice Maltret, Daniel Sidi, Damien Bonnet, and Younes Boudjemline.
    • Hôpital Necker-Enfants Malades, Paris, France.
    • J Am Soc Echocardiogr. 2009 Nov 1; 22 (11): 1289-95.

    ObjectiveLeft ventricular mechanical dyssynchrony has been poorly studied in the pediatric population with dilated cardiomyopathy. We investigated the degree of dyssynchrony in children with dilated cardiomyopathy using tissue Doppler imaging and speckle tracking strain.MethodsTwenty-five children with dilated cardiomyopathy were compared with healthy subjects. Left ventricular mechanical dyssynchrony was assessed by speckle tracking strain and tissue Doppler imaging. Both radial and longitudinal dyssynchrony were analyzed. Left ventricular end-diastolic diameter was measured to assess the relation between dyssynchrony and ventricular function and remodeling.ResultsRadial and longitudinal dyssynchrony parameters were significantly higher in the dilated cardiomyopathy group and correlated with Z-score left ventricular end-diastolic diameter. A logarithmic correlation between left ventricular ejection fraction and left ventricular end-diastolic diameter parameters was found.ConclusionIn children with dilated cardiomyopathy, tissue Doppler imaging and speckle tracking strain allowed the detection of dyssynchrony, which correlates with the severity of left ventricular function.

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