• Nicole M De La Peña, Kimberly K Amrami, and Robert J Spinner.
• Mayo Clinic Alix School of Medicine, Scottsdale, Arizona, USA. Electronic address: Delapena.Nicole@mayo.edu.
• World Neurosurg. 2022 Jan 1; 157: 21-29.

BackgroundAlthough partial cystic degeneration is commonly observed in schwannoma, cases of totally cystic forms have also been reported. A literature review of cases describing totally cystic schwannoma was performed to assess their imaging characteristics.MethodsPubMed was queried with the phrases "totally cystic schwannoma," "purely cystic schwannoma," and "completely cystic schwannoma." A total of 19 papers encompassing 22 cases of reported totally cystic schwannoma were included. Patient characteristics, clinical presentation, and reported imaging characteristics were recorded. Computed tomography and magnetic resonance images from the papers were collected and reviewed by a senior musculoskeletal radiologist.ResultsThe most frequent presenting location of these lesions was in spinal nerve roots. The interpretations of imaging reported in the papers described a homogeneous lesion that was isointense to slightly hyperintense to cerebrospinal fluid (CSF) on T1-weighted images. On contrast administration, the studies described a thin rim of "ring-like" enhancement around the lesion. Our reinterpretation of the imaging revealed heterogeneous lesions that were hyperintense to CSF on T1-weighted images. Post-contrast images typically demonstrated an irregularly thickened enhancing rim. Most images showed evidence of solid components in the lesion, with many containing enhancing soft tissue elements. The observed imaging features were not consistent with simple cystic lesions.ConclusionsReview of the imaging studies of the reported cases of completely cystic schwannoma did not produce any convincing examples of purely cystic lesions. The description of these lesions as "totally cystic" appears to be a misnomer and has diagnostic and therapeutic implications.Copyright © 2021 Elsevier Inc. All rights reserved.

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