• J. Neurol. Neurosurg. Psychiatr. · Dec 2021

    Anxiety and depression symptoms after COVID-19 infection: results from the COVID Symptom Study app.

    • Kerstin Klaser, Ellen J Thompson, Long H Nguyen, Carole H Sudre, Michela Antonelli, Benjamin Murray, Liane S Canas, Erika Molteni, Mark S Graham, Eric Kerfoot, Liyuan Chen, Jie Deng, Anna May, Christina Hu, Andy Guest, Somesh Selvachandran, David A Drew, Marc Modat, Andrew T Chan, Jonathan Wolf, Tim D Spector, Alexander Hammers, Emma L Duncan, Sebastien Ourselin, and Claire J Steves.
    • School of Biomedical Engineering & Imaging Sciences, King's College London, London, UK.
    • J. Neurol. Neurosurg. Psychiatr. 2021 Dec 1; 92 (12): 125412581254-1258.

    BackgroundMental health issues have been reported after SARS-CoV-2 infection. However, comparison to prevalence in uninfected individuals and contribution from common risk factors (eg, obesity and comorbidities) have not been examined. We identified how COVID-19 relates to mental health in the large community-based COVID Symptom Study.MethodsWe assessed anxiety and depression symptoms using two validated questionnaires in 413148 individuals between February and April 2021; 26998 had tested positive for SARS-CoV-2. We adjusted for physical and mental prepandemic comorbidities, body mass index (BMI), age and sex.FindingsOverall, 26.4% of participants met screening criteria for general anxiety and depression. Anxiety and depression were slightly more prevalent in previously SARS-CoV-2-positive (30.4%) vs SARS-CoV-2-negative (26.1%) individuals. This association was small compared with the effect of an unhealthy BMI and the presence of other comorbidities, and not evident in younger participants (≤40 years). Findings were robust to multiple sensitivity analyses. Association between SARS-CoV-2 infection and anxiety and depression was stronger in individuals with recent (<30 days) versus more distant (>120 days) infection, suggesting a short-term effect.InterpretationA small association was identified between SARS-CoV-2 infection and anxiety and depression symptoms. The proportion meeting criteria for self-reported anxiety and depression disorders is only slightly higher than prepandemic.© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

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