• Acta cardiologica · Feb 2004

    Left ventricular thrombosis is associated with increased mean platelet volume in patients with dilated cardiomyopathy and sinus rhythm.

    • Mehmet Birhan Yilmaz, Yesim Akin, Senay Funda Biyikoglu, Umit Guray, Halil L Kisacik, and Sule Korkmaz.
    • Yuksek Ihtisas Hospital, Cardiology Clinic, Sihhiye, Ankara, Turkey. cardioceptor@ttnet.net.tr
    • Acta Cardiol. 2004 Feb 1; 59 (1): 41-5.

    ObjectiveDilated cardiomyopathy has been associated with left ventricular thrombosis, which leads to substantial morbidity and mortality as a site for peripheral emboli. There are some studies on patients with dilated cardiomyopathy showing altered haemostasis and platelet behaviour despite sinus rhythm. Mean platelet volume, which is the most accurate and simple estimate of platelet reactivity, may be associated with the development of left ventricular thrombosis.Methods And ResultsWe prospectively enrolled 48 consecutive patients with dilated cardiomyopathy and sinus rhythm with left ventricular thrombosis and compared them with an age-sex-matched control group having dilated cardiomyopathy without left ventricular thrombosis. We found that in patients with left ventricular thrombosis mean platelet volume is significantly higher than those without (9.5 +/- 0.8 vs. 8.7 +/- 0.6, p < 0.001).ConclusionsMean platelet volume is increased in patients with dilated cardiomyopathy and sinus rhythm having left ventricular thrombosis. This might be reflecting a causal relationship, which in turn requires further study to establish the role of antiplatelet agents both in prevention and in treatment.

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