• Abdullah Sukun and Bulent Cekic.
• Department of Radiology, Kars Harakani State Hospital, Kars Harakani Devlet Hastanesi, Yenisehir Mah, İsmail Aytemiz Blv. No: 55 36200, Kars, Turkey. abdullah.sukun@gmail.com.
• Ir J Med Sci. 2022 Aug 1; 191 (4): 1899-1903.

BackgroundB-type natriuretic peptide (BNP) levels increase with an increase in intracranial pressure. A decrease in BNP levels has been found to be associated with patient positive prognosis. Brain-derived neurotrophic factor (BDNF) levels decrease in patients with acute stroke.AimsTo compare the BNP and BDNF values in serum before and after elective endovascular cerebral aneurysm treatment (ECAT).MethodsA total of 50 patients who underwent elective ECAT were included in the study. Exclusion criteria were determined to be history of heart failure or heart attack (n = 8), renal failure (n = 5), subarachnoid hemorrhage (n = 4), or previous aneurysm clip procedure (n = 3). Intravenous blood samples were obtained from 30 patients who underwent elective ECAT before and after treatment. After centrifugation, the BNP and BDNF values in serum were obtained with the ELISA method and compared.ResultsThis study included 19 female and 11 male patients, aged between 24 and 75 years. The average age of the patients was 51.27 ± 13.31 years. The median BDNF values did not change significantly after ECAT (before the endovascular procedure: 3.1 ± 1.3 pg/dl; after the endovascular procedure: 2.8 ± 0.9 pg/dl, p = 0.16). Median BNP levels decreased significantly after ECAT (before the endovascular procedure: 617.50 ± 483.11 pg/ml; after the endovascular procedure: 395.00 ± 352.15 pg/ml, p < 0.001).ConclusionsAfter elective endovascular cerebral aneurysm treatment, the BNP values in serum decreased significantly, and the BDNF values in serum did not change significantly.© 2021. The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland.

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