• Thromb Haemostasis · Sep 1999

    Review

    TNK-tPA for acute myocardial infarction: the clinical experience.

    • S V Pislaru and F Van de Werf.
    • Department of Cardiology, University of Leuven, Belgium.
    • Thromb Haemostasis. 1999 Sep 1; 82 Suppl 1: 117-20.

    AbstractThrombolytic therapy has become the mainstay of treatment for acute transmural myocardial infarction. Present fibrinolytic regimens have a number of shortcomings, including the failure to induce early and sustained reperfusion in as many as 40-50% of the patients, and to prevent reocclusion in another 10-20% of the patients. The efforts for improving thrombolysis are focused on the development of new agents (fibrinolytics, anticoagulants, and antiplatelet agents). TNK-tPA is a triple combination mutant of wild-type tissue plasminogen activator that exhibits a longer plasma half-life, an enhanced fibrin-specificity, and an increased resistance to the plasminogen activator inhibitor-1. This paper summarizes the results of clinical trials with TNK-tPA in acute myocardial infarction.

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