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The bone & joint journal · May 2013
ReviewBone graft substitutes currently available in orthopaedic practice: the evidence for their use.
- T Kurien, R G Pearson, and B E Scammell.
- Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom
- Bone Joint J. 2013 May 1; 95-B (5): 583-97.
AbstractWe reviewed 59 bone graft substitutes marketed by 17 companies currently available for implantation in the United Kingdom, with the aim of assessing the peer-reviewed literature to facilitate informed decision-making regarding their use in clinical practice. After critical analysis of the literature, only 22 products (37%) had any clinical data. Norian SRS (Synthes), Vitoss (Orthovita), Cortoss (Orthovita) and Alpha-BSM (Etex) had Level I evidence. We question the need for so many different products, especially with limited published clinical evidence for their efficacy, and conclude that there is a considerable need for further prospective randomised trials to facilitate informed decision-making with regard to the use of current and future bone graft substitutes in clinical practice.
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