• P Williams-Russo, N E Sharrock, S Mattis, T P Szatrowski, and M E Charlson.
• Department of Medicine, Hospital for Special Surgery, Cornell University Medical College, New York, NY 10021, USA.
• JAMA. 1995 Jul 5;274(1):44-50.

ObjectiveTo compare the effect of epidural vs general anesthesia on the incidence of long-term cognitive dysfunction after total knee replacement surgery in older adults.DesignRandomized controlled clinical trial.SettingOrthopedic specialty academic hospital.PatientsA total of 262 patients undergoing elective primary total knee replacement with a median age of 69 years; 70% women.InterventionRandom assignment to either epidural or general anesthesia.Main Outcome MeasuresA thorough neuropsychological assessment was performed preoperatively and repeated at 1 week and 6 months postoperatively. Cognitive outcome was assessed by within-patient change on 10 tests of memory, psychomotor, and language skills. Prospective standardized surveillance for cardiovascular complications was performed to allow simultaneous assessment of anesthetic effects on cognitive and cardiovascular outcomes.ResultsThe two groups were similar at baseline in terms of age, sex, comorbidity, and cognitive function. There were no significant differences between the epidural and general anesthesia groups in within-subject change from baseline on any of the 10 cognitive test results at either 1 week or 6 months. Overall, 5% of patients showed a long-term clinically significant deterioration in cognitive function. There was no difference between the anesthesia groups in the incidence of major cardiovascular complications (3% overall).ConclusionsThe type of anesthesia, general or epidural, does not affect the magnitude or pattern of postoperative cognitive dysfunction or the incidence of major cardiovascular complications in older adults undergoing elective total knee replacement. This is the largest trial of the effects of general vs regional anesthesia on cerebral function reported to date, with more than 99% power to detect a clinically significant difference on any of the neuropsychological tests.

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