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Anaesth Intensive Care · Oct 1996
Comparative StudyInhaled aerosolized prostacyclin and nitric oxide as selective pulmonary vasodilators in ARDS--a pilot study.
- P V Van Heerden, D Blythe, and S A Webb.
- Department of Intensive Care, Sir Charles Gairdner Hospital, Perth, Western Australia.
- Anaesth Intensive Care. 1996 Oct 1; 24 (5): 564568564-8.
AbstractNitric oxide 10 ppm and inhaled aerosolized prostacyclin 50 ng/kg/min were compared as selective pulmonary vasodilators in five patients with hypoxaemia secondary to acute respiratory distress syndrome. Neither agent resulted in systemic haemodynamic changes, indicating true pulmonary selectivity. Inhaled aerolized prostacyclin improved oxygenation to a degree comparable to nitric oxide, as measured by the arterial alveolar oxygen partial pressure gradient and shunt fraction.
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